Hyperbaric oxygen therapy has been widely used clinically, and its indications can be roughly divided into three categories:

　　Category 1: Hyperbaric oxygen therapy as the main treatment method can achieve significant effects of diseases.

　　Including: acute carbon monoxide poisoning and its toxic encephalopathy, acute decompression sickness, acute air embolism, suffocation caused by drowning, smoking, self-hanging, anesthesia accidents, etc., gas gangrene, head trauma and brain contusion and laceration, brain Brain dysfunction caused by concussion, hematoma removal, hydrogen sulfide, liquefied petroleum gas, phosgene, ammonia, gasoline and other harmful gases, acute fundus blood supply disorder, acute cerebral edema, chronic periodontitis, etc.

　　The second category: hyperbaric oxygen therapy as one of the comprehensive treatment measures, can significantly improve the efficacy of the disease.

　　Including: cerebral ischemic disease, brain dysfunction after cardiopulmonary resuscitation, drug poisoning with brain, pulmonary edema and hypoxemia, severe neurasthenia, migraine, spinal cord and peripheral nerve injury, peripheral neuritis, altitude insufficiency , Radiation osteonecrosis, osteomyelitis, fracture and poor healing, inactive fundus hemorrhage, sudden deafness, vertigo syndrome, vasculitis, Raynaud’s disease, arteriosclerosis obliterans and other peripheral vascular diseases, myocarditis, tetanus , Bronchial asthma, chronic gastrointestinal ulcers, viral encephalitis and its sequelae.

　　Three categories: hyperbaric oxygen therapy has a certain curative effect, and need to be further explored.

　　Including: meningitis, early optic atrophy, glaucoma, psoriasis, progressive muscular dystrophy, diabetes, etc.

　　In addition, hyperbaric oxygen therapy, as an auxiliary treatment method, has a good effect on replantation of severed limbs (finger), skin transplantation, cerebral hemorrhage lesion removal, and crush injuries. As an adjuvant therapy for malignant tumor radiotherapy, chemotherapy, various surgical adjuvant therapy, and anti-aging, it also has a certain effect, and is currently undergoing further research.

　　Oxygen poisoning

　　The oxygen in the atmosphere accounts for about 21%. Human beings were born in such an environment. After a long period of evolutionary adaptation, various physiological functions of the human body have adapted to the environment with normal oxygen content. Just as hypoxia breaks the body's own metabolic balance, too much oxygen intake will also break the body's own metabolic balance. However, the human body's tolerance to oxygen-rich environments is higher than that of other animals, and there is almost no natural environment that is highly oxygen-rich, and there is very little chance of ingesting too much oxygen. It was not until the advent of hyperbaric oxygen that the medical community discovered and confirmed the side effect of excessive intake of oxygen, oxygen poisoning.

　　Using a closed breathing mask to inhale high-concentration oxygen (above 60%), and after a certain period of time, or inhalation of oxygen under high pressure for a certain period of time, it will cause oxygen poisoning. For example, continuous oxygen inhalation for 2 hours and 5 minutes at 2 atmospheres can cause convulsions; at 3 atmospheres, the twitching time is only 37 minutes. Under 2.5 atmospheres, oxygen inhalation continues for 7 hours and 48 minutes. Continue to inhale oxygen for 6 hours and 20 minutes at an atmospheric pressure, which can reduce lung capacity by 10%. The main symptom at this time is chest pain and coughing when inhaling deeply.

　　This is due to excessive inhalation of pure oxygen, which inhibits or even inactivates the activity of more than 20 kinds of hydroxyl (SH)-containing deoxyalcohols and coenzymes, which seriously affects the metabolic processes related to the transfer of hydrogen. Excessive inhalation of pure oxygen will also significantly affect the cycle of sampic acid, the oxidative phosphorylation system in cell mitochondria will be destroyed, and the formation of high-energy phosphoric acid groups will be affected. It will also produce excessive free oxygen in the affected tissues.

　　Due to excessive inhalation of pure oxygen, the dissolved oxygen in the plasma has basically met the needs of the tissue, and the oxygen combined with hemoglobin is no longer dissociated, which affects the transportation and discharge of a considerable part of carbon dioxide, promotes the accumulation of carbon dioxide in the tissue, and increases the acidity. It also affects normal metabolism.

　　The effects of oxygen poisoning are systemic, causing functional or organic damage to the whole body. Due to the different sensitivity of various organs, it is usually only prominent in the lungs and other surface mucous membranes and capillaries; it can cause damage to the central nervous system, and can also cause damage to the brain, lungs, and eyes to varying degrees, and it may also cause hemolysis. .

　　The clinical symptoms of oxygen poisoning are: pale complexion, cold sweats, dizziness, nausea, and even convulsions; foot pain, cough, and shortness of breath. Some patients experience cell hemolysis. Oxygen poisoning in pregnant women will make the vision of immature babies deteriorate after birth.

　　Inhaling oxygen under normal pressure, whether you use a single nasal plug to inhale 100% pure oxygen, or use a closed breathing mask to inhale oxygen with a concentration of less than 70%, it is very safe, and the oxygen inhalation time does not need to be limited. If you use an airtight oxygen mask to inhale 100% pure oxygen, you should pause the oxygen inhalation 4 times within 24 hours, 15-20 minutes each time, and only inhale air during the intermittent period. It should be noted that for patients with chronic respiratory failure, the time and concentration of inhaling high-concentration oxygen should follow the doctor's advice.

　　It is impossible to cause oxygen poisoning by inhaling oxygen with a nasal cannula under normal pressure. This is because when the nasal cannula is used to inhale oxygen under normal pressure, the nasal cannula is only placed in one nostril and the flow rate is low. When breathing, one nostril inhales pure oxygen, and the other nostril inhales air. After mixing in the nasal cavity, the oxygen concentration will not exceed 50%, so it is very safe and will never cause oxygen poisoning. Patients who are given oxygen therapy due to hypoxia are less likely to suffer from oxygen poisoning. In our many years of medical work, we have never seen patients with oxygen poisoning during normal pressure oxygen inhalation; even patients treated in hyperbaric oxygen chambers, as long as they strictly control the one-time threshold of hyperbaric oxygen pressure, they rarely occur. Cases of oxygen poisoning.